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Studies looking at BAX and BAK genenegative mice have determined that Tregs use LAG ligation of DC MHC class II (see below)induce DC apoptosis in a mitochondrial-induced fashion (Chen 2011). The data are then grouped in a frequencytable so that, for each score value, the number of cases obtaining that score is shown inthe frequency (f) column.

Macroscopically, the area ofdemyelination is often triangular- or butterfl y-shapedand symmetrical in transverse sections.

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These diseases involve defects in the function ofTregs because of their special requirements for survival.